15-Deoxy-Δ12,14-prostaglandin J2 as an electrophilic mediator
نویسندگان
چکیده
منابع مشابه
Rac1 modification by an electrophilic 15-deoxy Δ12,14-prostaglandin J2 analog
Vascular endothelial cells (ECs) are important for maintaining vascular homeostasis. Dysfunction of ECs contributes to cardiovascular diseases, including atherosclerosis, and can impair the healing process during vascular injury. An important mediator of EC response to stress is the GTPase Rac1. Rac1 responds to extracellular signals and is involved in cytoskeletal rearrangement, reactive oxyge...
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Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) appear to have no connection with cancers. In the view of cell death, however, common ground can be found between neuronal and non-neuronal diseases [1]. AD and PD are ascribed to the cell death of neurons, which should be alive under healthy conditions. In contrast, cancers are attributed to the proliferat...
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Prototypical electrophiles such as the lipid 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) are well recognized for their therapeutic potential. Electrophiles modify signalling proteins in both the cytosol and mitochondrion, which results in diverse cellular responses, including cytoprotective effects and, at high doses, cell death. These findings led us to the hypothesis that targeting electr...
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Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligandactivated transcription factors that are related to retinoid, steroid, and thyroid hormone receptors. The PPARreceptor subtype seems to play a pivotal role in the regulation of cellular proliferation and inflammation. Recent evidence also suggests that the cyclopentenone prostagl...
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Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary-University of London, Charterhouse Square, London EC1M 6BQ, UK Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy Department of Pathology, University of Aberdeen, Aberdeen, UK Department of Medicine and Therapeutics, University of...
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ژورنال
عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry
سال: 2015
ISSN: 0916-8451,1347-6947
DOI: 10.1080/09168451.2015.1012149